abstract：:Prostate cancer is a significant health concern. In the early stages, prostate cancer cells depend on androgens for growth and survival, hence androgen-ablation therapy at this time may be effective in causing tumor regression. However, treatment options for advanced hormone-refractory prostate cancers are still relat...

journal_title：Oncology letters

authors： Zhu G,Wang X,Yang Z,Cao H,Meng Z,Wang Y,Chen D

更新日期：2011-11-01 00:00:00

abstract：:Glucose Transporter 1 (GLUT1) belongs to the expanding mammalian facilitative glucose transporter family. Elevated GLUT1 protein expression has been observed in the majority of urothelial carcinomas, with various effects on clinicopathological parameters. Whereas malignant cells have an accelerated metabolism with inc...

journal_title：Oncology letters

authors： Reis H,Tschirdewahn S,Szarvas T,Rübben H,Schmid KW,Grabellus F

更新日期：2011-11-01 00:00:00

abstract：:erbB-2 is amplified or overexpressed in approximately 30% of human breast cancers, and has been associated with poor prognosis and therapeutic resistance. Previous studies have suggested that erbB-2 overexpression in transgenic mice induces genomic instability; however, the patterns of genetic lesions vary with indivi...

journal_title：Oncology letters

authors： Kim YM,Ma Z,Lee S,Lee J,Li S,Yang X

更新日期：2011-11-01 00:00:00

abstract：:The molecule DRO1 (down‑regulated by oncogenes 1) is a potential tumor suppressor protein that is frequently down‑regulated in primary colorectal cancers and colorectal cancer cell lines. Although the mechanism of DRO1 action has yet to be elucidated, previous data have suggested that DRO1 interferes with tumor growth...

journal_title：Oncology letters

authors： Herbst A,Bayer C,Wypior C,Kolligs FT

更新日期：2011-09-01 00:00:00

abstract：:The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...

journal_title：Oncology letters

authors： Zhou Z,Ware JH,Kennedy AR

更新日期：2011-09-01 00:00:00

abstract：:The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...

journal_title：Oncology letters

authors： Komatsu T,Oizumi Y,Kunieda E,Tamai Y,Akiba T,Kogawa A

更新日期：2011-09-01 00:00:00

abstract：:A 62-year-old male patient underwent endoscopic mucosal resection (EMR). Additional hybrid 2-port hand-assisted laparoscopic surgery (HALS) (Mukai's operation) was performed for early rectal cancer located at the distal border of the rectum/below the peritoneal reflection (Rb) region [SM massive invasion/ly+/vertical ...

journal_title：Oncology letters

authors： Mukai M,Sekido Y,Fukumitsu H,Izumi H,Hoshikawa T,Tajima T,Tobita K,Sadahiro S,Yasuda S,Ogoshi K

更新日期：2011-09-01 00:00:00

abstract：:The aim of this study was to objectively evaluate the benefits of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy for early-stage cervical cancer. Clinical data were prospectively collected from patients with IA-IIB cervical cancer who underwent laparoscopically assisted vaginal radical hyst...

journal_title：Oncology letters

authors： Hou CY,Li XL,Jiang F,Gong RJ,Guo XY,Yao YQ

更新日期：2011-07-01 00:00:00

abstract：:This study investigated the inhibitory effect of vitamin D-binding protein-derived macrophage-activating factor (GcMAF) on carcinogenesis and tumor growth, using a 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster cheek pouch carcinogenesis model, as well as the cytocidal effect of activated macrophages against ...

journal_title：Oncology letters

authors： Toyohara Y,Hashitani S,Kishimoto H,Noguchi K,Yamamoto N,Urade M

更新日期：2011-07-01 00:00:00

abstract：:Retroperitoneal primary mucinous adenocarcinoma (RPMA) is extremely rare and the histogenesis of this tumor remains unclear. There is no consensus on the appropriate treatment for RPMA. Surgical resection is standard for the treatment of RPMA, whereas the benefits of chemotherapy with regard to this tumor remain to be...

journal_title：Oncology letters

authors： Jiang H,Jin K,You Q,Fang W,Xu N

更新日期：2011-07-01 00:00:00

abstract：:The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known for the immune-enhancing activity of its polysaccharide. However, little is known about another of its major constituents, triterpene. This study investigated the anticancer mechanism of a triterpene...

journal_title：Oncology letters

authors： Ji Z,Tang Q,Hao R,Zhang J,Pan Y

更新日期：2011-05-01 00:00:00

abstract：:A standard therapeutic approach for advanced malignant thymoma has yet to be defined given the rarity of this condition. We present a patient with advanced thymoma, evaluated as inoperable at diagnosis due to multiple serosal metastases. The strong constitution and determination of the patient allowed treatment with s...

journal_title：Oncology letters

authors： Bergonzi M,Orlandoni G,Corbella F,Gobbi PG

更新日期：2011-05-01 00:00:00

abstract：:Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication characterized by intimal proliferation in pulmonary small arteries and arterioles with or without tumor emboli. In the majority of cases, the causative lesion is gastric poorly differentiated adenocarcinoma. In the present stu...

journal_title：Oncology letters

authors： Hotta M,Ishida M,Kojima F,Iwai Y,Okabe H

更新日期：2011-05-01 00:00:00

abstract：:The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...

journal_title：Oncology letters

authors： Xu L,Zeng Z,Chen B,Wu X,Yu J,Xue L,Tian L,Wang Y,Chen M,Sung JJ,Hu P

更新日期：2011-03-01 00:00:00

abstract：:This study investigated the mRNA levels of thymidylate synthetase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) in esophageal squamous cell carcinoma (ESCC). TYMS and DPYD gene expression was quantified using real-time RT-PCR in 56 patients with ESCC, co-amplified with glyceraldehyde-3-phosphate dehydrogenase as a...

journal_title：Oncology letters

authors： Kimura M,Kuwabara Y,Mitsui A,Ishiguro H,Sugito N,Tanaka T,Shiozaki M,Naganawa Y,Takeyama H

更新日期：2011-03-01 00:00:00

abstract：:Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immuno...

journal_title：Oncology letters

authors： Oue N,Noguchi T,Anami K,Sentani K,Sakamoto N,Uraoka N,Wakamatsu Y,Sasaki H,Yasui W

更新日期：2011-03-01 00:00:00

abstract：:Selective amino acid restriction targets mitochondria to induce apoptosis of DU145 and PC3 prostate cancer cells. Biochemical assays and flow cytometry were uitilized to analyze the glucose consumption, lactate production, pyruvate dehydrogenase (PDH), nicotinamide adenine dinucleotide (NAD)/NADH and nicotinamide aden...

journal_title：Oncology letters

authors： Liu X,Fu YM,Meadows GG

更新日期：2011-01-18 00:00:00

abstract：:To define the correlation between BCR promoter DNA methylation and response to imatinib in chronic myeloid leukemia (CML), we investigated BCR promoter DNA methylation in three groups of subjects. The first group included chronic phase patients enrolled in an imatinib dose escalation trial. In the trial, patients who ...

journal_title：Oncology letters

authors： Koh Y,Kim DY,Park SH,Byun HM,Kim I,Yoon SS,Kim BK,Park E,Yang AS,Park S

更新日期：2011-01-01 00:00:00

abstract：:Nordihydroguaiaretic acid (NDGA) and its derivatives possess anti-cancer effects on various types of cancer via the induction of apoptosis or cell cycle arrest. This study proved that NDGA inhibited cervical cancer SiHa cell growth and induced cell cycle arrest at the G(1) phase, which may be a consequence of cell cyc...

journal_title：Oncology letters

authors： Gao P,Zhai F,Guan L,Zheng J

更新日期：2011-01-01 00:00:00

abstract：:This study aimed to determine the relationship between human papillomavirus (HPV) and nuclear factor-κB (NF-κB) in cervical cancer using 62 tissues of cervical cancer, and to compare the findings to penile cancer. HPV-DNA integration is a crucial factor for malignant transformation in cervical cancer and can be identi...

journal_title：Oncology letters

authors： Senba M,Buziba N,Mori N,Fujita S,Morimoto K,Wada A,Toriyama K

更新日期：2011-01-01 00:00:00

abstract：:We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings sug...

journal_title：Oncology letters

authors： Moyano MS,Gutiérrez-Gutiérrez G,Rodríguez-Esteban I,Crespo GS,Casado E

更新日期：2010-11-01 00:00:00

abstract：:To detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate their significance, the expression of let-7 and K-ras was determined in cancerous tissues and pericancerous normal tissues of 31 NSCLC patients using reverse transcription-polymerase chain reac...

journal_title：Oncology letters

authors： Xia XM,Jin WY,Shi RZ,Zhang YF,Chen J

更新日期：2010-11-01 00:00:00

abstract：:The monolocular cystic formation associated with gallbladder carcinoma is an extremely rare condition. A 79-year-old female suffering from upper abdominal pain and distention was admitted to our hospital. Ultrasonography and computed tomography revealed a monolocular cyst with an irregular wall thickness of 15 cm in d...

journal_title：Oncology letters

authors： Hiraki M,Yakushiji H,Hashiguchi K,Harada S,Kohya N,Kai K,Yamaguchi K,Mori D,Irie K,Tokunaga O,Noshiro H,Miyazaki K

更新日期：2010-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a re...

journal_title：Oncology letters

authors： Yanokura M,Banno K,Kobayashi Y,Kisu I,Ueki A,Ono A,Masuda K,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2010-11-01 00:00:00

abstract：:The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28...

journal_title：Oncology letters

authors： Gu F,Ma Y,Fan Y,Lang R,Ding T,Hao X,Gong Y,Kobayahsi H,Fang Z,Fu L

更新日期：2010-09-01 00:00:00

abstract：:Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro ci...

journal_title：Oncology letters

authors： Inoue Y,Matsumoto H,Yamada S,Kawai K,Suemizu H,Gika M,Takanami I,Iwazaki M,Nakamura M

更新日期：2010-09-01 00:00:00

abstract：:Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...

journal_title：Oncology letters

authors： Jaœkiewicz K,Iżycka-Œwieszewska E,Janiak M,Lysiak-Szydłowska W,Adrych K,Reinartz J,Jankun J,Skrzypczak-Jankun E

更新日期：2010-09-01 00:00:00

abstract：:Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...

journal_title：Oncology letters

authors： Köllermann J,Albrecht H,Schlomm T,Huland H,Graefen M,Bokemeyer C,Simon R,Sauter G,Wilczak W

更新日期：2010-07-01 00:00:00

abstract：:Studies conducted in our lab have indicated that thalidomide cytotoxicity in the KG-1a human acute myelogenous leukemia (AML) cell line was enhanced by combining it with arsenic trioxide. The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic ...

journal_title：Oncology letters

authors： Girgis EH,Mahoney JP,Khalil RH,Soliman MR

更新日期：2010-07-01 00:00:00

abstract：:Human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16(INK4a), p53 and nuclear factor κB (NF-κB). In the present stud...

journal_title：Oncology letters

authors： Senba M,Mori N,Fujita S,Jutavijittum P,Yousukh A,Toriyama K,Wada A

更新日期：2010-07-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two human colon carcinoma cell lines, DLD-1 and WiDr. Colon carcinoma cells were treated with various concentrations of aloe-emodin for different durations. Cell viability was m...

journal_title：Oncology letters

authors： Lin KY,Uen YH

更新日期：2010-05-01 00:00:00

abstract：:Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in ...

journal_title：Oncology letters

authors： Yamamoto M,Suzuki SO,Himeno M

更新日期：2010-05-01 00:00:00

abstract：:The risk factors for the development of hepatocellular carcinoma (HCC) in patients who have achieved a long-term sustained viral response (SVR) to interferon (IFN) are not fully understood. This study aimed to investigate the characteristics of patients who developed HCC after 10 years of achieving SVR. We retrospecti...

journal_title：Oncology letters

authors： Nojiri K,Sugimoto K,Shiraki K,Kusagawa S,Tanaka J,Beppu T,Yamamoto N,Takei Y,Hashimoto A,Shimizu A,Omori S,Tameda M,Takase K

更新日期：2010-05-01 00:00:00

abstract：:For osteoblastoma, with its predilection for the spinal column and appendicular skeleton, the skull is an unusual site, and paranasal sinus involvement is very rare. Herein, we report on a case in which the disease was located within the sphenoid bone. To the best of our knowledge, this is the 4th reported case of ost...

journal_title：Oncology letters

authors： Kukwa W,Oziębło A,Oecińska A,Czarnecka AM,Włodarski K,Kukwa A

更新日期：2010-03-01 00:00:00

abstract：:The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...

journal_title：Oncology letters

authors： Banik BK,Mukhopadhyay C,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:For individualized bevacizumab-based therapy, non-invasive biomarkers are necessary. This study assessed the predictive value of plasma vascular endothelial growth factor (VEGF)-A, soluble VEGF receptor (sVEGFR)-1 and sVEGFR-2 levels as biomarkers for clinical response and survival in advanced colorectal cancer (CRC) ...

journal_title：Oncology letters

authors： Aoyagi Y,Iinuma H,Horiuchi A,Shimada R,Watanabe T

更新日期：2010-03-01 00:00:00

abstract：:The Mantle Cell Lymphoma International Prognostic Index (MIPI) combines four factors to differentiate low-, intermediate- and high-risk prognostic groups in advanced mantle cell lymphoma using data from patients treated in clinical trials. To evaluate its use in routine practice, we applied the simplified index retros...

journal_title：Oncology letters

authors： Lim SY,Horsman JM,Hancock BW

更新日期：2010-01-01 00:00:00

abstract：:The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...

journal_title：Oncology letters

authors： Ogose A,Hotta T,Shibata M,Kawashima H,Endo N

更新日期：2010-01-01 00:00:00

abstract：:The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous in...

journal_title：Oncology letters

authors： Inoue Y,Tanaka K,Hiro J,Toiyama Y,Miki C,Kusunoki M

更新日期：2010-01-01 00:00:00

abstract：:The present study evaluated the expression of p53, pRb, hMLH1 and MDM2 prior to preoperative chemoradiotherapy (CRT) in patients with rectal cancer, and attempted to determine any correlation with treatment outcome. Forty-five patients with available pretreatment biopsy tissues and who received preoperative CRT were e...

journal_title：Oncology letters

authors： Nam TK,Lee JS,Kim HR,Ahn SJ,Song JY,Yoon MS

更新日期：2010-01-01 00:00:00